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1 1 1 2 2 1 1 6 3

31 (62%) 48 (96%) 7 (14%) 27 (54%) 34 (68%) 50 (100%)

Fifty animals were examined per group. Dose was given in corn oil by gavage 5 days per week. Historical incidence of hepatocellular adenoma or carcinoma: 2.5 2.8%, range 0 10% (male rats), 1.2 2.7%, range 0 10% (female rats); 35.1 11.0%, range 14 52% (male mice); 10.1 4.3%, range 2 16% (female mice). a Reference 4.

2 1 1 1 1

Progressive JPEG Each component in a sequential scan requires two Huffman tables (DC and AC) In progressive JPEG a scan will use either DC tables or AC tables, but not both In fact, a refining progressive DC scan does not use Huffman tables at all It is entirely possible for a progressive DC scan to occur in a JPEG file before any AC Huffman tables have been defined, something that is illegal in sequential JPEG

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2. Hepatocellular adenomas and carcinomas: Hepatocellular neoplasms were induced in both sexes of rats and mice at furan low-dose levels of 2 and 8 mg/kg bw, respectively (Table 2.4.8). The increase in incidence was dose-related. Hepatocellular neoplasms were not observed at the 9- or 15-month interim evaluation in rats. Background (control mice) incidence of hepatocellular adenoma/carcinoma in male mice was high (52%). Hepatocellular carcinoma was rst observed at the 15-month interim evaluation in 2 of the 10 male rats dosed with 30 mg/kg for 13 weeks of a stop-exposure study. 3. Mononuclear cell leukemia: Incidence was increased in male and female rats at 4 and 8 mg/kg dose levels (Table 2.4.9). 4. Benign pheochromocytoma of the adrenal medulla: Incidence was increased in male mice at 8 and 15 mg/kg bw and in female mice at 15 mg/kg bw (Table 2.4.9).

TABLE 2.4.9 Incidence of mononuclear cell leukemia in rats and lesions of the adrenal medulla in mice in the NTP 2-year gavage study.a Furan, mg/kg Neoplasm/lesion Mononuclear cell leukemia Male rats, % Female rats, % Adrenal medulla Male mice Focal hyperplasia, % Benign pheochromocytoma, % Female mice Focal hyperplasia, % Benign pheochromocytoma, % 0 16 16 2 22 18 4 34 34 8 50 42 15

2 1 2 20 21 6 2 10

0 2 4 4

Data Unit Decoding First DC Scans The process for decoding the first scan for DC coefficients is nearly identical to that for DC coefficients in a sequential scan (see 8) The only difference is that the point transform is applied to the decoded DC value (left-shifted by the successive approximation value) before being stored as a coefficient value Algorithm 111 illustrates the decoding of a data unit GLOBAL SUCCESSIVEAPPROXIMATION GLOBAL LAST_DC_VALUE Procedure FirstDCDataunit (COEFFICIENTS [063]) Begin BITCOUNT = DecodeUsingDCHuffmanTable () BITS = ReadLiteralBits (BITCOUNT) DCDIFFERENCE = Extent (BITS, BITCOUNT) DCVALUE = DCDIFFERENCE + LAST_DC_VALUE LAST_DC_VALUE = DCVALUE COEFFICIENTS [II] = DCVALUE LeftShift SUCCESSIVEAPPROXIMATION End

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+ + + + + + + + + + + + + + 8 8 27 18 11 12 7 13 188 46 173 1 87 6 65 117 23 57 54 40 64 1 85 21 1 14 7 5 29 12 4

18 20 16 12

Fifty animals were examined per group. Dose was given in corn oil by gavage 5 days per week. Historical incidence of mononuclear cell leukemia of vehicle controls: 21.3 8.9%, range 4 38% (male rats) and 26.8 7.0%, range 16 38% (female rats). Historical incidence of benign pheochromocytoma of vehicle controls: 2.7 1.6%, range 0 4% (male mice) and 1.5 2.4%, range 0 8% (female mice). a Reference 4.

(Continued)

The NTP studies demonstrated that furan induced cytotoxic and carcinogenic effects at all doses tested in rats and mice, and a no observed adverse effect level (NOAEL) was not identi ed A recent study by Moser et al (G Moser, 2007, personal communication) examined the hypothesis that cytotoxicity and cell proliferation may play a role in the liver tumor formation in female mice treated with furan Like the NTP bioassay, female B6C3F1 mice were exposed to furan, 5 days a week, by gavage in corn oil for 3 weeks or 2 years Furan dosages included the carcinogenic doses used in the NTP bioassay and lower dosages of 0, 05, 10, 20, 40, and 80 mg/kg bw There was a dose response relationship between the incidence of liver tumors and the induction of cytotoxicity and cell proliferation.

Refining DC Scans Refining DC scans are the simplest of all JPEG scans to handle The scan's compressed data consists entirely of raw data bits, one bit per data unit Algorithm 112 shows all the processing required to process a data unit in this type of scan

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